Klawiatura Titanum Tk101 Usb Sterown

Klawiatura Titanum Tk101 Usb Sterown

klawiatura titanum tk101 usb sterown
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klawiatura titanum tk101 usb sterownSubchronic oral toxicity study of radiolabeled Cu-ATSM in Sprague-Dawley rats.
A subchronic oral toxicity study with [(64)Cu] copper-(II)-bis(triazatetraazacyclohexyl)sulfonamide ([(64)Cu]Cu-ATSM) was performed to investigate the oral absorption, distribution, metabolism, and excretion of [(64)Cu]Cu-ATSM. Male and female Sprague-Dawley rats were divided into three dose groups (0, 1000, and 2000 mg/kg/day) and one control group. All rats received [(64)Cu]Cu-ATSM (dose of 0.2 mCi/kg, oral administration) for 21 days. The radioactivity was measured in blood, urine, feces, liver, spleen, kidney, and the major organs. The results showed that the median lethal dose (LD50) of [(64)Cu]Cu-ATSM was over 2000 mg/kg for both sexes. The maximal absorbed dose (0.923 ± 0.093 mGy/MBq) and the absorbed dose rate (5.29 ± 1.08 mGy/MBq/h) were in the range of values reported for humans. Following oral administration, radioactivity was absorbed rapidly and the activity was distributed to various tissues such as the liver, kidney, and spleen after 90 min. The radioactivity in the liver (5.95-9.63 mBq/g) was about four times that of the spleen (1.74-2.90 mBq/g) after 90 min. Meanwhile, in the urine, the radioactivity peaked at about 120 min. After that, it declined very slowly with little excretion; the feces showed less than 7% of the activity administered. The results of this study indicate that a dose of about 1.0 mCi/kg [(64)Cu]Cu-ATSM is safe for oral administration to rats when the exposure is limited to

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